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. 2021 Oct 6;15:674745. doi: 10.3389/fnins.2021.674745

FIGURE 3.

FIGURE 3

CI-994 restores Drd2 gene expression in the striatum but not in the prefrontal cortex of aged mice. (A) Aged mice showed a significant decrease of Drd2 mRNA expression as compared to young mice (aged VEH vs. young VEH, p = 0.0007), however, HAL treatment did not impact Drd2 mRNA expression (aged VEH vs. aged HAL, p = 0.9050). CI-994 20 mg/kg with HAL significantly increased Drd2 expression (aged VEH vs. aged CI-994 + HAL 20 mg/kg, p = 0.0060; aged HAL vs. aged CI-994 + HAL 20 mg/kg, p < 0.0001). However, CI-994 20 mg/kg treatment alone did not have an effect on Drd2 mRNA expression (aged CI-994 20 mg/kg vs. aged VEH, p = 0.6034). (B) Chronic treatment of CI-994 at 20 mg/kg alone or combined with HAL did not increase Drd2 mRNA expression in the prefrontal cortex of aged mice. Data represent mean ± SEM (n = 4/per group). **p < 0.01, ***p < 0.001, ****p < 0.0001, NS, not significant.