Table 2.
The univariate analysis for association between FA features at the vascular-avascular junction with development of treatment-requiring ROP (N = 98 eyes).
| FA characteristics | # eyes | Treatment (%) | OR (95% CI) | P valuea (linear trend p valueb) |
|---|---|---|---|---|
| Finger-like anastomosis | 0.20 (0.73) | |||
| None | 19 | 5 (26.3%) | 1 | |
| Mild | 28 | 7 (25.0%) | 0.93 (0.24, 3.64) | |
| Moderate or severe | 21 | 6 (28.6%) | 1.12 (0.24, 5.13) | |
| Ungradable | 30 | 3 (10.0%) | 0.31 (0.09, 1.03) | |
| Shunts | 0.04 (0.008) | |||
| None/mild | 24 | 2 (8.3%) | 1 | |
| Moderate | 21 | 6 (28.6%) | 4.40 (0.92, 21.0) | |
| Severe | 22 | 10 (45.5%) | 9.17 (1.65, 50.8) | |
| Ungradable | 31 | 3 (9.7%) | 1.18 (0.18, 7.86) | |
| Tangles | 0.10 (0.12) | |||
| None | 16 | 1 (6.3%) | 1 | |
| Mild | 23 | 8 (34.8%) | 8.00 (0.86, 74.6) | |
| Moderate | 20 | 7 (35.0%) | 8.08 (0.84, 77.9) | |
| Severe | 8 | 2 (25.0%) | 5.00 (0.39, 64.3) | |
| Ungradable | 31 | 3 (9.7%) | 1.61 (0.15, 17.0) | |
| Hyperfluorescent lesions | 0.01 (0.002) | |||
| None | 38 | 2 (5.3%) | 1 | |
| Mild | 18 | 9 (50.0%) | 18.0 (3.07, 106) | |
| Moderate/severe | 11 | 7 (63.6%) | 31.5 (4.81, 206) | |
| Ungradable | 31 | 3 (9.7%) | 1.93 (0.43, 8.58) | |
| Leakage | 0.02 (0.007) | |||
| None | 24 | 1 (4.2%) | 1 | |
| Mild | 30 | 10 (33.3%) | 11.5 (1.29, 103) | |
| Moderate/severe | 13 | 7 (53.9%) | 26.8 (2.56, 282) | |
| Ungradable | 31 | 3 (9.7%) | 2.46 (0.24, 25.6) | |
| Capillary obliteration | 0.09 (0.01) | |||
| None/mild/moderate | 44 | 9 (20.5%) | 1 | |
| Severe | 25 | 9 (36.0%) | 2.19 (0.76, 6.32) | |
| Ungradable | 29 | 3 (10.3%) | 0.45 (0.11, 1.81) |
aFor comparison of treatment rate difference across all groups of grading including ungradable, and inter-eye correlation was accounted for by using Generalized estimating equation.
bThe comparison of treatment rate difference across groups excluding ungradable using test of linear trend, and inter-eye correlation was accounted for by using Generalized estimating equation.