Table 1.
54 Down-regulated proteins in Scz organoids (<−0.5 Log2FC, p < 0.05).
| Gene Name | Protein Name | Uniprot ID | Log2FC | P Value |
|---|---|---|---|---|
| GAP43 | Neuromodulin | P17677 | −1.183 | 0.010 |
| CRABP1 | Cellular retinoic acid-binding protein 1 | P29762 | −1.018 | 0.016 |
| TUBB3 | Tubulin beta-3 chain | Q13509 | −1.015 | 0.001 |
| MAP2 | Microtubule-associated protein 2 | P11137-3 | −0.996 | 0.009 |
| BASP1 | Brain acid soluble protein 1 | P80723 | −0.939 | 0.006 |
| INA | Alpha-internexin | Q16352 | −0.921 | 0.035 |
| FABP7 | Fatty acid-binding protein, brain | O15540 | −0.903 | 0.025 |
| SV2A | Synaptic vesicle glycoprotein 2A | Q7L0J3-2 | −0.899 | 0.037 |
| PKM | Pyruvate kinase PKM | P14618-2 | −0.866 | 0.004 |
| NCAM1 | Neural Cell Adhesion Molecule | A0A087WTF6 | −0.854 | 0.014 |
| CALM3 | Calmodulin-3 | P0DP25 | −0.847 | 0.002 |
| TUBB2B | Tubulin beta-2B chain | Q9BVA1 | −0.840 | 0.019 |
| TNNI1 | Troponin I 1 | G3V489 | −0.827 | 0.037 |
| ATP1A3 | Sodium/potassium-transporting ATPase subunit alpha-3 | P13637 | −0.817 | 0.042 |
| CRMP1 | Dihydropyrimidinase-related protein 1 | Q14194 | −0.789 | 0.019 |
| RUFY3 | Protein RUFY3 | Q7L099 | −0.774 | 0.014 |
| ATAT1 | Alpha-tubulin N-acetyltransferase 1 | Q5SQI0-7 | −0.773 | 0.023 |
| PEA15 | Astrocytic phosphoprotein PEA-15 | Q15121 | −0.764 | 0.030 |
| H1-0 | Histone H1.0 | P07305-2 | −0.760 | 0.009 |
| NCALD | Neurocalcin-delta | P61601 | −0.738 | 0.000 |
| PPM1B | Protein phosphatase 1B | O75688 | −0.714 | 0.030 |
| TAGLN3 | Transgelin-3 | Q9UI15 | −0.705 | 0.001 |
| PTN | Pleiotrophin | P21246 | −0.700 | 0.030 |
| CRIP2 | Cysteine-rich protein 2 | P52943 | −0.690 | 0.005 |
| RAB6B | Ras-related protein Rab-6B | Q9NRW1 | −0.684 | 0.010 |
| ENO2 | Gamma-enolase | P09104-2 | −0.682 | 0.027 |
| TUBB4A | Tubulin beta-4A chain | P04350 | −0.676 | 0.008 |
| DPYSL5 | Dihydropyrimidinase-related protein 5 | Q9BPU6 | −0.673 | 0.001 |
| SEPTIN3 | Neuronal-specific septin-3 | Q9UH03-2 | −0.667 | 0.015 |
| GDI1 | Rab GDP dissociation inhibitor alpha | P31150 | −0.659 | 0.011 |
| FHL1 | Four and a half LIM domains protein 1 | Q13642-1 | −0.658 | 0.010 |
| TUBA1A | Tubulin alpha-1A chain | Q71U36-2 | −0.653 | 0.019 |
| MARCKS | Myristoylated alanine-rich C-kinase substrate | P29966 | −0.650 | 0.002 |
| UCHL1 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | P09936 | −0.629 | 0.033 |
| LAMA4 | Laminin subunit alpha-4 | Q16363-2 | −0.619 | 0.016 |
| TCEAL3 | Transcription elongation factor A protein-like 3 | Q969E4 | −0.614 | 0.044 |
| TUBB4B | Tubulin beta-4B chain | P68371 | −0.595 | 0.014 |
| H3-2 | Histone HIST2H3PS2 | Q5TEC6 | −0.574 | 0.001 |
| PTMS | Parathymosin | P20962 | −0.565 | 0.008 |
| PALM | Paralemmin-1 | O75781-2 | −0.552 | 0.000 |
| RTN1 | Reticulon-1 | Q16799-3 | −0.551 | 0.038 |
| FBN3 | Fibrillin-3 | Q75N90 | −0.538 | 0.010 |
| MYEF2 | Myelin Expression Factor 2 | A0A087WUT0 | −0.537 | 0.001 |
| H2AC20 | Histone H2A type 2-C | Q16777 | −0.531 | 0.008 |
| DPYSL2 | Dihydropyrimidinase-related protein 2 | Q16555 | −0.529 | 0.014 |
| MAP1B | Microtubule-associated protein 1B | P46821 | −0.527 | 0.020 |
| HDGFL3 | Hepatoma-derived growth factor-related protein 3 | Q9Y3E1 | −0.517 | 0.002 |
| CKB | Creatine kinase B-type | P12277 | −0.513 | 0.037 |
| KIF5C | Kinesin heavy chain isoform 5C | O60282 | −0.512 | 0.014 |
| SCRN1 | Secernin-1 | Q12765 | −0.510 | 0.004 |
| HP1BP3 | Heterochromatin protein 1-binding protein 3 | Q5SSJ5 | −0.509 | 0.000 |
| H3C1 | Histone H3.1 | P68431 | −0.502 | 0.010 |
| CPE | Carboxypeptidase E | D6RF88 | −0.501 | 0.040 |
| HSDL1 | Inactive hydroxysteroid dehydrogenase-like protein 1 | Q3SXM5-2 | −0.501 | 0.021 |