Table 7.
Down-regulated reactome pathways in Scz organoids (p < 0.05).
| Reactome pathway | Reactome Term_ID | Adjusted p-value | Neg Log10 adjusted p |
|---|---|---|---|
| L1CAM Interactions | REAC:R-HSA-373760 | 4.04E−07 | 6.393 |
| Microtubule-Dependent Trafficking of Connexons from Golgi to the Plasma Membrane | REAC:R-HSA-190840 | 7.37E−07 | 6.133 |
| Transport of Connexons to the Plasma Membrane | REAC:R-HSA-190872 | 9.65E−07 | 6.015 |
| Recycling Pathway of L1 | REAC:R-HSA-437239 | 1.35E−06 | 5.869 |
| Post-Chaperonin Tubulin Folding Pathway | REAC:R-HSA-389977 | 2.00E−06 | 5.698 |
| COPI-Independent Golgi-to-ER Retrograde Traffic | REAC:R-HSA-6811436 | 2.51E−06 | 5.601 |
| Formation of Tubulin Folding Intermediates by CCT/TriC | REAC:R-HSA-389960 | 3.09E−06 | 5.510 |
| Activation of AMPK Downstream of NMDARs | REAC:R-HSA-9619483 | 4.59E−06 | 5.338 |
| Prefoldin Mediated Transfer of Substrate to CCT/TriC | REAC:R-HSA-389957 | 4.59E−06 | 5.338 |
| Sealing of the Nuclear Rnvelope (NE) by ESCRT-III | REAC:R-HSA-9668328 | 9.34E−06 | 5.030 |
| RHO GTPases Activate IQGAPs | REAC:R-HSA-5626467 | 9.34E−06 | 5.030 |
| Cooperation of Prefoldin and TriC/CCT in Actin and Tubulin Folding | REAC:R-HSA-389958 | 1.10E−05 | 4.959 |
| Gap Junction Assembly | REAC:R-HSA-190861 | 2.30E−05 | 4.638 |
| HCMV Early Events | REAC:R-HSA-9609690 | 3.03E−05 | 4.518 |
| Assembly and Cell Surface Presentation of NMDA Receptors | REAC:R-HSA-9609736 | 4.36E−05 | 4.360 |
| Aggrephagy | REAC:R-HSA-9646399 | 4.91E−05 | 4.309 |
| Carboxyterminal Post-Translational Modifications of Tubulin | REAC:R-HSA-8955332 | 6.18E−05 | 4.209 |
| Gap Junction Trafficking | REAC:R-HSA-190828 | 8.54E−05 | 4.069 |
| HCMV Infection | REAC:R-HSA-9609646 | 9.31E−05 | 4.031 |
| Gap Junction Trafficking and Regulation | REAC:R-HSA-157858 | 9.47E−05 | 4.024 |
| Intraflagellar Transport | REAC:R-HSA-5620924 | 0.000140206 | 3.853 |
| HSP90 Chaperone Cycle for Steroid Hormone Receptors (SHR) | REAC:R-HSA-3371497 | 0.000184495 | 3.734 |
| Kinesins | REAC:R-HSA-983189 | 0.000259999 | 3.585 |
| Nuclear Envelope (NE) Reassembly | REAC:R-HSA-2995410 | 0.000519297 | 3.285 |
| Translocation of SLC2A4 (GLUT4) to the Plasma Membrane | REAC:R-HSA-1445148 | 0.000597876 | 3.223 |
| Golgi-to-ER Retrograde Transport | REAC:R-HSA-8856688 | 0.000664661 | 3.177 |
| Axon Guidance | REAC:R-HSA-422475 | 0.00067359 | 3.172 |
| Post NMDA Receptor Activation Events | REAC:R-HSA-438064 | 0.000783019 | 3.106 |
| The Role of GTSE1 in G2/M Progression after G2 Checkpoint | REAC:R-HSA-8852276 | 0.000949362 | 3.023 |
| Nervous System Development | REAC:R-HSA-9675108 | 0.001007002 | 2.997 |
| Selective Autophagy | REAC:R-HSA-9663891 | 0.001010583 | 2.995 |
| Activation of NMDA Receptors and Postsynaptic Events | REAC:R-HSA-442755 | 0.00171304 | 2.766 |
| Recruitment of NuMA to Mitotic Centrosomes | REAC:R-HSA-380320 | 0.002242316 | 2.649 |
| Chaperonin-Mediated Protein Folding | REAC:R-HSA-390466 | 0.002362049 | 2.627 |
| Factors Involved in Megakaryocyte Development and Platelet Production | REAC:R-HSA-983231 | 0.002639065 | 2.579 |
| COPI-Dependent Golgi-to-ER Retrograde Traffic | REAC:R-HSA-6811434 | 0.003037982 | 2.517 |
| COPI-Mediated Anterograde Transport | REAC:R-HSA-6807878 | 0.003347233 | 2.475 |
| Protein Folding | REAC:R-HSA-391251 | 0.003347233 | 2.475 |
| CRMPs in Sema3A Signaling | REAC:R-HSA-399956 | 0.003988868 | 2.399 |
| Hedgehog ‘off’ State | REAC:R-HSA-5610787 | 0.005515212 | 2.258 |
| Neurotransmitter Receptors and Postsynaptic Signal Transmission | REAC:R-HSA-112314 | 0.005949918 | 2.225 |
| EML4 and NUDC in Mitotic Spindle Formation | REAC:R-HSA-9648025 | 0.006005753 | 2.221 |
| Cilium Assembly | REAC:R-HSA-5617833 | 0.006863941 | 2.163 |
| Intra-Golgi and Retrograde Golgi-to-ER traffic | REAC:R-HSA-6811442 | 0.007259898 | 2.139 |
| Resolution of Sister Chromatid Cohesion | REAC:R-HSA-2500257 | 0.008317829 | 2.080 |
| MHC Class II Antigen Presentation | REAC:R-HSA-2132295 | 0.008317829 | 2.080 |
| RHO GTPase Effectors | REAC:R-HSA-195258 | 0.0094632 | 2.024 |
| Developmental Biology | REAC:R-HSA-1266738 | 0.011666055 | 1.933 |
| Macroautophagy | REAC:R-HSA-1632852 | 0.012565891 | 1.901 |
| RHO GTPases Activate Formins | REAC:R-HSA-5663220 | 0.013491876 | 1.870 |
| Signaling by Hedgehog | REAC:R-HSA-5358351 | 0.02087328 | 1.680 |
| Autophagy | REAC:R-HSA-9612973 | 0.02087328 | 1.680 |
| ER to Golgi Anterograde Transport | REAC:R-HSA-199977 | 0.025184333 | 1.599 |
| Transmission across Chemical Synapses | REAC:R-HSA-112315 | 0.028395357 | 1.547 |
| M Phase | REAC:R-HSA-68886 | 0.044247896 | 1.354 |