Table 8.
Up-regulated reactome pathways in Scz organoids (p < 0.05).
| Reactome pathway | Reactome Term_ID | Adjusted p-value | Neg Log10 adjusted p |
|---|---|---|---|
| Post-Translational Protein Phosphorylation | REAC:R-HSA-8957275 | 8.31E−09 | 8.080 |
| Chylomicron Assembly | REAC:R-HSA-8963888 | 1.82E−08 | 7.739 |
| Chylomicron Remodeling | REAC:R-HSA-8963901 | 1.82E−08 | 7.739 |
| Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | REAC:R-HSA-381426 | 3.18E−08 | 7.498 |
| Plasma Lipoprotein Assembly | REAC:R-HSA-8963898 | 6.10E−07 | 6.215 |
| Retinoid Metabolism and Transport | REAC:R-HSA-975634 | 1.25E−06 | 5.902 |
| Metabolism of Fat-Soluble Vitamins | REAC:R-HSA-6806667 | 2.16E−06 | 5.665 |
| Plasma Lipoprotein Remodeling | REAC:R-HSA-8963899 | 9.87E−06 | 5.006 |
| Platelet Degranulation | REAC:R-HSA-114608 | 3.04E−05 | 4.517 |
| Response to Elevated Platelet Cytosolic Ca2+ | REAC:R-HSA-76005 | 3.98E−05 | 4.400 |
| Regulation of TLR by Endogenous Ligand | REAC:R-HSA-5686938 | 0.000100533 | 3.998 |
| Visual Phototransduction | REAC:R-HSA-2187338 | 0.000156361 | 3.806 |
| Metabolism of Vitamins and Cofactors | REAC:R-HSA-196854 | 0.000455116 | 3.342 |
| Plasma Lipoprotein Assembly, Remodeling, and Clearance | REAC:R-HSA-174824 | 0.000616778 | 3.210 |
| HDL remodeling | REAC:R-HSA-8964058 | 0.000786847 | 3.104 |
| Hemostasis | REAC:R-HSA-109582 | 0.001130796 | 2.947 |
| GRB2:SOS Provides Linkage to MAPK Signaling for Integrins | REAC:R-HSA-354194 | 0.003373717 | 2.472 |
| Platelet Activation, Signaling and Aggregation | REAC:R-HSA-76002 | 0.003972412 | 2.401 |
| p130Cas Linkage to MAPK Signaling for Integrins | REAC:R-HSA-372708 | 0.004208218 | 2.376 |
| Scavenging by Class A Receptors | REAC:R-HSA-3000480 | 0.008886469 | 2.051 |
| Common Pathway of Fibrin Clot Formation | REAC:R-HSA-140875 | 0.014033493 | 1.853 |
| Integrin Signaling | REAC:R-HSA-354192 | 0.023493017 | 1.629 |
| Chylomicron Clearance | REAC:R-HSA-8964026 | 0.032311883 | 1.491 |
| Scavenging by Class B Receptors | REAC:R-HSA-3000471 | 0.032311883 | 1.491 |
| Integrin Cell Surface Interactions | REAC:R-HSA-216083 | 0.043417684 | 1.362 |
| Plasma Lipoprotein Clearance | REAC:R-HSA-8964043 | 0.044251662 | 1.354 |