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. 2021 Oct 19;12:6000. doi: 10.1038/s41467-021-26209-8

Fig. 8. Microbial rewiring of host metabolism and gut-brain axis exhibits gender-specific characteristics.

Fig. 8

a Proportions of ion features with significant main effects of microbiota as determined by two-way analysis of variance (ANOVA) (adjusted p < 0.05). b Proportions of ion features with significant main effects of gender as determined by two-way ANOVA (adjusted p < 0.05). c–e Pie charts for gender-specific distribution of ion features in feces (c), sera (d), and cerebral cortical brain (e) combining both HESI positive and negative modes that had main effects of microbiota (two-way ANOVA, adjusted p < 0.05) while exhibiting statistical GF/CONV-R difference in at least one gender (post hoc Tukey’s HSD test, adjusted p < 0.05). f–h PieDonut charts for gender-specific distribution of the identified compounds in feces (f), sera (g), and cerebral cortical brain (h) as determined by two-way ANOVA (adjusted p < 0.05) and post hoc Tukey’s HSD test (adjusted p < 0.05).