Fig. 5. Neutralization profiles for the iB-series of nAbs as well as for some of the previously reported reference nAbs tested against WT and selected amino acid residue mutant pseudoviruses (positions 406–501 aa).

a Heatmap displaying nAb IC₅₀ fold change, when tested against a single amino acid mutant virus relative to WT. Asterisks denote mutations that are absent from the currently circulating viral isolates and which have been shown to confer resistance to some of the clinical-stage nAbs. b Heatmap displaying nAb sensitivity to double and triple mutations in the RBD, which correspond to the substitutions found in several currently circulating VOCs.