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. 2021 Oct 19;11:20674. doi: 10.1038/s41598-021-99880-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of anti-IL-11 antibody (X203) treatment on post-endothelial injury injury-related plaque fibrosis. (A) MMP2 positive staining per injury-related plaque (N = 11/group, One-way ANOVA, Tukey’s multiple comparison test, Values ± SD). (B) Representative images of MMP2 immunofluorescence staining (green, scale bar 100 μm). Insets represent higher magnification of positive cells inside the restenosis plaque (scale bar 50 μm). Transparent red-lines were traced to delineate the injury-related plaque area used for quantifications. (C) Collagen content (blue) of the injury-related plaque (N = 11/group, One-way ANOVA, Tukey’s multiple comparison test Values ± SD). (D) Representative images of Gomori stain (collagen in blue, muscle in red, scale bar 50 μm). (E) Collagen content (blue) of right, uninjured carotid arteries (N = 12–14/group, One-way ANOVA, Tukey’s multiple comparison test Values ± SD). (F) Representative images of Gomori stain (collagen in blue, muscle in red, scale bar 50 μm).