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. 2021 Oct 6;8:750355. doi: 10.3389/fnut.2021.750355

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Copyright © 2021 Zhang, Tang, Xu, Hui, Lu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of TRPV1 receptor antagonist and capsaicin on protein (A,B) and mRNA (C) expression levels of key genes for glycometabolism in liver of STZ-induced diabetic rats. All data are expressed as means ± SD, n = 8. ^*Means are significant difference compared with the control group (P < 0.05). Means with different superscript letters are significantly different among the diabetes groups (P < 0.05). G6pase, glucose 6 phosphatase; GLUT2, glucose transporter 2; PEPCK, phosphoenolpyruvate carboxykinase; TRPV1, transient receptor potential cation channel subfamily V member 1; LXR, liver X receptor; PDX-1, pancreatic duodenal homeobox 1; GK, glucokinase. Effective concentrations of capsaicin and capsazepine are 6 and 10 mg/kg·BW, respectively.