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. 2021 Oct 6;8:750355. doi: 10.3389/fnut.2021.750355

Figure 5.

Figure 5

Effects of TRPV1 receptor antagonist and capsaicin on protein (A,B) and mRNA (C) expression levels of key genes for glycometabolism in pancreas of STZ-induced diabetic rats. All data are expressed as means ± SD, n = 8. *Means are significant difference compared with the control group (P < 0.05). Means with different superscript letters are significantly different among the diabetes groups (P < 0.05). TRPV1, transient receptor potential cation channel subfamily V member 1; PDX-1, pancreatic duodenal homeobox-1; IRS1, insulin receptor substrate 1; IRS2, insulin receptor substrate 2; GLUT2, glucose transporter 2. Effective concentrations of capsaicin and capsazepine are 6 and 10 mg/kg·BW, respectively.