Table 1.
Effects of TRPV1 receptor antagonist and capsaicin on weight and apparent absorption of TS in STZ-induced diabetic rats.
| Project | Control | Diabetes groups | |||
|---|---|---|---|---|---|
| Model | CPZ | Cap | Cap+CPZ | ||
| Food intake (g/d) | 26.2 ± 1.93 | 46.3 ± 2.07a | 43.5 ± 1.28b | 34.7 ± 1.00c | 39.8 ± 1.58d |
| Sugar intake (g/d) | 12.7 ± 0.93 | 22.4 ± 1.00a | 21.0 ± 0.62b | 16.8 ± 0.48c | 19.2 ± 0.76d |
| Fecal excretion (g/d) | 2.83 ± 0.19 | 4.99 ± 0.23a | 4.52 ± 0.16b | 3.77 ± 0.10c | 4.32 ± 0.17d |
| Sugar in feces (%) | 27.4 ± 3.47 | 36.8 ± 6.00a | 35.1 ± 3.78a | 58.6 ± 2.65b | 25.9 ± 1.09c |
| Sugar excretion (g/d) | 0.78 ± 0.15 | 1.85 ± 0.38a | 1.59 ± 0.20b | 2.21 ± 0.13c | 1.12 ± 0.05d |
| Apparent absorptivity (%) | 97.8 ± 0.17 | 98.3 ± 0.34a | 98.3 ± 0.17a | 96.5 ± 0.21b | 98.6 ± 0.10c |
| Body weight (0 day) | 265 ± 7.42 | 264 ± 7.96 | 260 ± 18.09 | 261 ± 15.26 | 260 ± 17.48 |
| End body weight (28 day) | 324 ± 14.31 | 275 ± 7.40 | 275 ± 17.10 | 288 ± 16.11 | 280 ± 13.78 |
| Body weight gain (g) | 59.9 ± 16.70 | 11.1 ± 3.27a | 15.4 ± 5.15a | 27.1 ± 8.84b | 19.6 ± 7.09ab |
All data are expressed as means ± SD, n = 8. Bold means are significant difference compared with the control group (P < 0.05). Means with different superscript letters are significantly different among the diabetes groups (P < 0.05). Effective concentrations of capsaicin and capsazepine are 6 and 10 mg/kg·bw, respectively.