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Larger proteins display a similar anisotropic distribution of coupling free energies. The color code is maintained the same as Fig. 3 for the proteins glucocorticoid receptor (panels A, B, C), adenylate kinase (panels D, E, F) and beta-2 adrenergic receptor (panels G, H, I). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
