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. 2021 Oct 19;11:20697. doi: 10.1038/s41598-021-00052-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Differential global histone methylation/acetylation patterns related to obstructive sleep apnea (OSA) and its clinical phenotypes. Both (A) global histone H3K23Ac and (B) H3K36 Ac expressions were decreased in OSA patients. (C) H3K23Ac expression was negatively correlated with apnea hypopnea index (AHI). H3K36Ac expression was negatively correlated with both (D) AHI and (E) oxygen desaturation index (ODI), and positively with (F) minimum oxygen saturation (SaO2). (G) H3K23Ac expression was further decreased in OSA patients with prevalent hypertension. (H) H3K79me3 expression was increased in OSA patients with high serum hypersensitivity C-reactive protein (hsCRP) levels. *adjust for age, body mass index, gender, smoking history, alcoholism history, and co-morbidities (diabetes mellitus, hypertension, stroke, cardiac disease, chronic kidney disease) by multivariate linear regression analysis. #compared between primary snoring (PS) subjects and obstructive sleep apnea (OSA) patients with a particular phenotype (hypertension or high hsCRP), adjusted by multivariate linear regression analysis. ##compared between OSA patients with a particular phenotype (hypertension or high hsCRP) and those without the phenotype, adjusted by multivariate linear regression analysis. Hollow circle indicates PS subjects; solid star indicates OSA patients. PBMC = peripheral blood mononuclear cell; CI = confidence interval; HT = hypertension.