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. 2021 Oct 19;12:6084. doi: 10.1038/s41467-021-26131-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Illustration of the neuro-functional subtyping we used to identify the sub-population of ASD individuals enriched for Tsc2-mTOR network genes. RsfMRI connectivity mapping was applied to the heterogeneous population of ASD individuals followed by hierarchical clustering. Gene decoding and enrichment analysis were then applied to identify the ASD subtype that is most enriched for Tsc2/mTOR network genes. b The heatmap shows the four clusters identified with agglomerative hierarchical clustering. c Intergroup comparisons showed clear subtype-specific functional connectivity fingerprints, i.e., alterations of rsfMRI connectivity in ASD vs. TDs for each cluster. d Gene enrichment highlighted that only ASD subtype 2 was significantly enriched for mTOR/Tsc2 genes. **P < 0.01.