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. 2021 Oct 6;12:676182. doi: 10.3389/fgene.2021.676182

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Copyright © 2021 Unni, Reddy, Pal, Sagi and Galande.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of Hippo pathway homologs in Hydra. (A) Domain architecture of the homologs as visualized using DOG 2.0. (B) Depicts the percent identity of Hydra homolog with Drosophila and Human. (C) Phylogenetic tree and domain organization of YAP homologs across the animal phyla. The phylogenetic analysis was carried out on NGphylogeny.fr webserver and the tree was generated using FastTree 2 method. Here, the phylogenetic tree was rooted at Amphimedon queenslandica YAP-like sequence (AMPQU). Domain organization analysis was carried out using DoMosaics software. Branch support values are displayed at the branching points. Different phyla are highlighted with distinct colours. Hydra YAP homologue (HVUL YAP) is highlighted in red colour font. A UNIPROT style abbreviations for organism names are used. Sequence details are provided in the Supplementary Table S4.