Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 6;12:744823. doi: 10.3389/fimmu.2021.744823

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Lin, Cheng, Mu, Zhou and Zhu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The structure of conventional CAR and modular CAR: (A) the first generation of CAR consists of an extracellular antigen-binding domain (usually the single chain variable fragment, scFv), a transmembrane domain, and an intracellular signaling domain of the CD3ζ chain. Then, a costimulator is added in the (B) second generation and more in the (C) third generation. (D) The fourth generation of CAR is modified further to secret a cytokine to enhance the function. (E) The modular CAR is split into two interactive parts, the signaling module on T cells and the switching module to recognize targets.