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Multiple gene or non-gene editing on UCAR-T cells. In addition to transducing a CAR into T cells, the TCR can be knocked out or inhibited to prevent GVHD. Genetic ablation of MHC-I and/or MHC-II diminish immunogenicity. Destruction of CD52 can make cells resistant to alemtuzumab. CD7 is edited to prevent the fratricide in CD7 UCAR-T cells. In addition, inhibitory checkpoints (e.g., PD-1) can be knocked out to enhance the function of cells.
