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. 2021 Oct 6;12:741934. doi: 10.3389/fimmu.2021.741934

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Copyright © 2021 Wen, He, Zhong, Zhao, Weng, Mi and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Stigmasterol regulates the Treg/Th17 balance in a gut microbiota-dependent manner. (A) The number of Treg cells in the spleen and MLNs in the ABX (water), ABX (DSS) and ABX (stigma + DSS) groups was analysed by flow cytometry. (B, C) Average number of CD4⁺Foxp3⁺ (Treg) cells among the CD4⁺ T-cell subsets in the spleen (B) and MLNs (C). (D) The number of Th17 cells in the spleen and MLNs in the ABX (water), ABX (DSS) and ABX (stigma + DSS) groups was analysed by flow cytometry. (E, F) Bar charts showing the percentage of CD4⁺IL17A⁺(Th17) cells in the spleen (E) and MLNs (F). (A–F) n = 3 mice per group. (G) Serum concentration of IL-10, TGF-β and IL-17A. n = 5 mice per group. (A–G) The data are representative of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001; n.s., not significant (P > 0.05).