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. 2021 Oct 6;9:743236. doi: 10.3389/fbioe.2021.743236

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Copyright © 2021 Carius, Dubois, Ajdarirad, Artzy-Schnirman, Sznitman, Schneider-Daum and Lehr.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of fluorescein sodium transport between Transwell and the perfusable platform under LCC. (A) Transport studies were performed on Calu-3 cells (LCC: d17-d19). TEER values were measured before the experiment (before), 1 h after the incubation in transport buffer (1 h after switch), as well as after the transport study (after) and indicated a stable barrier during the transport. (B) Apparent permeability (Papp) of fluorescein sodium (2.5 μg/ml (dose: 500 ng on Transwell; 212 ng on platform)) applied as a solution. Papp was determined after the transport study (7 h). Data represent mean ± S.D. (A) 2-way ANOVA was performed not assuming sphericity and with a Šídák´s multiple comparisons test, ns: p > 0.5; *: p < 0.05; **: p < 0.005; (B) Unpaired t-test was performed with Welch`s Correction; Transwell LCC: n = 9, Platform LCC: n = 6 out of 3 independent experiments.