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. 2021 Oct 6;12:754106. doi: 10.3389/fimmu.2021.754106

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Copyright © 2021 Goto, Ito, Satoh, Nakamoto, Nishizawa, Hosono, Naitoh, Eshima, Iwabuchi, Hiki and Amano

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cd1d^-/- mice exhibited delayed liver repair and macrophage differentiation during hepatic I/R injury. (A) ALT levels, hepatic necrosis, and PCNA⁺-hepatocytes (%), (B) the percentage of Ly6C^high macrophages (Ly6G^-/Ly6C^high/CD11b^high/F4/80^high cells) and Ly6C^low macrophages (Ly6G^-/Ly6C^low/CD11b^high/F4/80^high cells), and (C) expression of genes related to pro-inflammatory (Tnf, Il1b, Il6, Nos2, and Ifng) and reparative macrophages phenotypes (Mrc1, Retnla, Il4, and Il13) after hepatic I/R injury in WT and Cd1d^-/- mice. Data are expressed as the mean ± SD (six biological replicates per group). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.