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. 2021 Oct 6;11:733745. doi: 10.3389/fonc.2021.733745

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Copyright © 2021 Yang, Zhou, Zeng, Zhou, Wang, Li, Zhu, Guan and Chai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The oncogenic roles of circ-0002570 in the progression of GC cells. (A, B) RT-PCR determined the expression of circ-0002570 and FAM73A in AGS and SGC7901 cells transfected with NC-sh, circ-0002570-sh#1, or circ-0002570-sh#2. (C) CCK-8 assay presented the proliferation of AGS and SGC7901 cells transfected with NC-sh or circ-0002570-sh. (D) Edu assays determined the proliferative ability. (E) Colony formation assay in AGS and SGC7901 cells after circ-0002570 knockdown. (F) Migration of AGS and SGC7901 cells in different transfection groups was detected by scratch wound assays. (G, H) The migrative and invasive capacity of NC-sh or circ-0002570-sh transfected AGS and SGC7901 cells was assessed by transwell assays. (I) TUNEL was employed to analyze the apoptotic index. *p < 0.05, **p < 0.01, ***p < 0.001.