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. 2021 Oct 6;11:733745. doi: 10.3389/fonc.2021.733745

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Copyright © 2021 Yang, Zhou, Zeng, Zhou, Wang, Li, Zhu, Guan and Chai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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VCAN is a target of miR-587. (A) Potential miRNA binding to circ-0002570. mRNA–miR-587 interaction was predicted by miRanda and targetscan. (B) RT-PCR for the levels of the potential candidates in AGS cells after miR-587 overexpression. Luciferase reporter assay confirmed the molecular binding. (C, D) The expression of VCAN at mRNA and protein in AGS and SGC7901 cells after miR-587 dysregulation. (E, F) RT-PCR and Western blot determined the expression of VCAN at mRNA and protein in AGS and SGC7901 cells transfected with NC-sh, circ-0002570-sh, or circ-0002570-sh+miR-587 inhibitor. *p < 0.05, **p < 0.01, ***p < 0.001.