TABLE 5.
In vitro bacterial effects in presence of catecholamines (adhesion/invasion, cytotoxicity).
| Bacterial species | Catecholamines (dose) | Cell lines | In vitro effects | Antagonists | References |
| Aeromonas hydrophyla | Epi (100 μM) NE (100 μM) Dopamine (100 μM) |
HEp-2 epithelial cells | Increase of adhesion | n. | Dong et al., 2016 |
| Actinobacillus pleuropneumoniae | Epi (50 μM) NE (50 μM) |
SJPL lung cells | Adhesion induced by NE but not by Epi Cytotoxicity enhanced by Epi but repressed by NE | Phentolamine Propanolol | Li et al., 2012 |
| Campylobacter jejuni NCTC11168 | NE (100 μM) | Caco-2 intestinal cells | Increase of invasion Decrease of TEER Breakdown of tight junction (occludin) observed by CLSM | n. | Cogan et al., 2007 |
| Epi (100 μM) NE (100 μM) |
Caco-2 intestinal cells | Increase of adhesion/invasion | n. | Xu et al., 2015 | |
| Campylobacter species | NE (100 μM) | T84 epithelial cells | Increase of invasion for C. jejuni M1 and C. fetus fetus, not for C. jejuni 81116 and C. coli 1669 Decrease of TEER breakdown of tight junction (occludin) observed by CLSM | n. | Aroori et al., 2014 |
| Enterococcus faecalis | Epi (1 μM) NE (1 μM) |
Caco-2/TC7 intestinal cells HaCaT keratinocyte cells | Increase of adhesion | n. | Cambronel et al., 2020 |
| Salmonella enterica serovar Typhimurium | NE (50 μM) | HeLa epithelial cells | Increase of invasion | n. | Moreira and Sperandio, 2012 |
| Streptococcus pneumoniae | NE (50 μM) | A549 lung cells | Decrease of adhesion | n. | Gonzales et al., 2013 |
| Pseudomonas aeruginosa PAO1 | Epi (1 μM) | Caco-2/TC7 intestinal cells | Increase of adhesion/invasion and translocation Decrease in TEER | n. | Biaggini, 2015 |
| Pseudomonas aeruginosa PA14 | NE (50 and 500 μM) | HCT-8 intestinal cells | Increase of adhesion/invasion | n. | Hegde et al., 2009 |
| Pseudomonas fluorescens MFN1032 | Epi (1 μM) | Caco-2/TC7 intestinal cells | No effect on cytotoxicity Decrease of TEER F-actin cytoskeleton disorganization (CLSM observation) | n. | Biaggini et al., 2015 |
| Vibrio parahaemolyticus | NE (50 μM) | Caco-2 intestinal cells | Increase of cytotoxicity | Phentolamine Propanonol | Nakano et al., 2007b |
n, not used in the study; TEER, transepithelial electrical resistance; CLSM, confocal laser scanning microscope.