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. 2021 Aug 8;297(5):101063. doi: 10.1016/j.jbc.2021.101063

Figure 5.

Figure 5

AMPNPP binding supports PfK5ΔL6-MD cover neck bundle formation.A, no nucleotide PfK5ΔL6-MD model and corresponding cryo-EM density of the cover neck bundle region. Helixα6/neck linker, the N-terminus, and loop13 are colored according to the schematic. Note the lack of density for the neck linker at the terminus of helixα6. +/− symbols denote the MT polarity. Pink arrow indicates the lack of density for an ordered neck linker. B, as in (A) for the AMPPNP state (at equivalent density thresholds), showing density corresponding to the neck linker docked along the motor domain and cover neck bundle formation (CNB), which is highlighted by the dotted black circle.