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. 2021 Oct 6;12:725572. doi: 10.3389/fmicb.2021.725572

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Copyright © 2021 Suresh, Bradley, Higgs, Russo, Alqahtani, Huang, Bakshi and Malik.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nlrp3 deficiency results in enhanced survival of F. tularensis LVS-infected mice. (A–C) Survival graph of C57BL/6 wild-type and Nlrp3^−/− mice (n=6–8 mice/group) infected intranasally with indicated doses of F. tularensis LVS. The mice were observed for mortality for 21days. The data were analyzed by the Log-rank test and values of p were calculated. (D–F) The infected mice were weighed at the indicated times to monitor morbidity. ^*p<0.05; ^**p<0.01.