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. 2021 Oct 19;10(10):e1348. doi: 10.1002/cti2.1348

Figure 2.

Figure 2

TIGIT expression on immune cell subsets and impact of HIV‐1 and CMV infection. Correlation of TIGIT expression levels on (a) CD4+ T cells, (b) CD8+ T cells and (c) NK cells with CD4+ T‐cell nadir was evaluated for the PLWH cohort (n = 95) to gauge linkage with HIV‐1 disease progression. The extent of TIGIT expression on NK cells was plotted against the percentage of NK cells that were (d) CD57+NKG2C+ (n = 95) or (e) FcRγ‐ (n = 50) and correlation assessed. Individuals within the (f) PLWH or (g) HIV‐seronegative cohort were grouped based on CMV serostatus and NK cell TIGIT expression for those who were CMV‐seronegative (PLWH n = 18; HIV‐seronegative n = 5) was compared with those who were CMV‐seropositive (PLWH n = 77; HIV‐seronegative n = 21). Mann–Whitney U‐test *P = 0.0256. Horizontal lines bisecting groups in f and g represent median with IQR.