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. 2021 Oct 6;12:701721. doi: 10.3389/fimmu.2021.701721

Figure 1.

Figure 1

Left ventricular (LV) function is impaired in Stamp2 -/- mice when subjected to ischemia and reperfusion injury (I/R). (A) Representative echocardiographic recordings indicating enhanced reduction of LV function in Stamp2-/- hearts as compared to WT after 7 days of I/R (A=Apex, R= Aortic root; Diast.=diastole Syst.=systole). (B) Total ejection fraction (EF, n=9/9/9/9) and (C) change of EF in % to baseline (n=9/9). (D) Total cardiac output (CO, n=9/9/9/9) and (E) change of CO in % to baseline (n=9/9) as assessed by echocardiography. (F) Global longitudinal strain reduction after subjection to I/R (n=9/9). Baseline echocardiography was directly performed before MI induction and I/R echocardiography at day 7. Graphs show Mean ± SEM. Significance was determined by two-way ANOVA followed by Tukey post-hoc test (B, D) or by unpaired Student’s t-test (C, E, F). *P < 0.05, **P < 0.01, ***P < 0.001.