TABLE 2.
Protein partners possibly interacting indirectly with Pyk2.
| Partner | Comments | Reference |
| α1-actin, α2-actin, β-actin | pUS28-expressing U373 or RSMC; IP, tandem MS | Vomaske et al. (2010) |
| Abl-interactor-2 | pUS28-expressing U373; IP, tandem MS; low levels | Vomaske et al. (2010) |
| AF-17 | pUS28-expressing RSMC; IP, tandem MS | Vomaske et al. (2010) |
| Alpha-1,3/1,6-mannosyltransferase / ALG2 | Co-precipitation of FAK, Pyk2 | Schmidt et al. (2003) |
| Annexin VI / annexin A6 | COS-1, Rat-1; GST pull-down, co-IP; complex with Fyn, Pyk2, p120GAP | Chow et al. (2000) |
| ARF GTPase-activating protein GIT1 / CAT-1 | Ko et al. (2003) | |
| BiP | pUS28-expressing U373; IP, tandem MS | Vomaske et al. (2010) |
| Copine-5 | pUS28-expressing U373; IP, tandem MS; low levels | Vomaske et al. (2010) |
| Dynamin | Possibly mediated by Grb2 | Bruzzaniti et al. (2009) |
| E3 ubiquitin-protein ligase / Cbl /RING finger protein 56 | Osteoclasts, PC12, HEK293; co-IP; contributes to Pyk2 degradation. Involves Cbl C-terminal region | Sanjay et al. (2001); Schmidt et al. (2003); Haglund et al. (2004); Fan et al. (2014) |
| E3 ubiquitin-protein ligase CBLB / Cbl-b | MGC803; co-IP; contributes to Pyk2 degradation | Fan et al. (2014) |
| E3 ubiquitin-protein ligase NEDD4 | Pyk2 and FAK | Verma et al. (2017) |
| EGFR / ErbB-1 | Pyk2 and FAK, neurite outgrowth regulation | Ivankovic-Dikic et al. (2000); Keely et al. (2000) |
| ErbB-2 / HER2 / CD340 | Pyk2 mediates activation of MAP kinase by neuregulins. Involves Pyk2 pY402 | Zrihan-Licht et al. (2000) |
| ErbB-3 / HER3 | PYK2 regulates the degradation of HER3 | van der Horst et al. (2005); Verma et al. (2017) |
| F-actin capping proteins-a1, -a2, and –b | pUS28-expressing RSMC; IP, tandem MS; low levels | Vomaske et al. (2010) |
| GPIb-β; GPVI | Human platelets; co-IP; indirect | Arthur et al. (2011) |
| Grin2a, glutamate receptor ionotropic NMDA 2A, GluN2A, NR2A | See text | Liu et al. (2001); Seabold et al. (2003) |
| Grin2b, glutamate receptor ionotropic NMDA 2B, GluN2B, NR2B | See text | Seabold et al. (2003) |
| G-protein subunit alpha-13 (Gα13) | Pyk2 downstream of Gα13; Co-IP | Shi et al. (2000) |
| G-protein subunit beta-5 (Gβ5) | pUS28-expressing RSMC; IP, tandem MS; low levels | Vomaske et al. (2010) |
| Hsc70 | pUS28-expressing U373; IP, tandem MS | Vomaske et al. (2010) |
| Integrator complex subunit 6 | pUS28-expressing U373; IP, tandem MS | Vomaske et al. (2010) |
| Integrin beta-1 / CD29 / MDF2 | Possibly through PI3K | Melikova et al. (2004) |
| Integrin beta-2 / CD18 / MF17 | Pyk2 downstream of β2 not associated | Yan and Novak (1999); Miura et al. (2000); Evangelista et al. (2007) |
| Interleukin-7 receptor alpha (IL-7R-alpha) | Increased by IL-7 | Benbernou et al. (2000) |
| Janus kinase 1 (JAK1) | Increased by IL-7 | Benbernou et al. (2000) |
| Janus kinase 2 (JAK2) | Pyk2 associated with and downstream of Jak2; co-IP | Takaoka et al. (1999); Frank et al. (2002) |
| Janus kinase 3 (JAK3) | Increased by IL-2; co-IP | Miyazaki et al. (1998) |
| KSR-2 | pUS28-expressing RSMC; IP, tandem MS low levels | Vomaske et al. (2010) |
| Microtubule associated protein Tau | Tau Pyk2-substrate | Dourlen et al. (2017); Li and Gotz (2018) |
| Mortalin | pUS28-expressing U373; IP, tandem MS | Vomaske et al. (2010) |
| Myosin light chain-6 | pUS28-expressing RSMC; IP, tandem MS low levels | Vomaske et al. (2010) |
| Myosin-9 | pUS28-expressing U373; IP, tandem MS | Vomaske et al. (2010) |
| N-acetyltransferase-10 | pUS28-expressing U373; IP, tandem MS | Vomaske et al. (2010) |
| Nectin-3 | pUS28-expressing U373; IP, tandem MS | Vomaske et al. (2010) |
| NFkB p105 | pUS28-expressing RSMC; IP, tandem MS low levels | Vomaske et al. (2010) |
| NIM1 kinase | pUS28-expressing U373; IP, tandem MS | Vomaske et al. (2010) |
| Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1 / PI3K-p85) | Complex with integrin beta-1 / CD29 / MDF2 Co-IP | Melikova et al. (2004) |
| Potassium voltage-gated channel subfamily A member 2 (KCNA2 / Kv1.2 / NGK1) | Pyk2 phosphorylates and may inhibit Kv1.2; co-IP | Byron and Lucchesi (2002) |
| Programmed cell death 6-interacting protein (PDCD6-interacting protein) / ALG-2-interacting protein 1 (AIP1 /Alix) | Complex with SETA/CIN85/Ruk and AIP1; HEK293 cells; co-IP | Schmidt et al. (2003) |
| Protein kinase C, PKC-alpha | Complex with β1-integrin and PI3K; myeloma cells co-IP | Podar et al. (2002) |
| Protein kinase C, PKC-delta | Pancreatic acinar cells, co-IP | Wrenn (2001) |
| PTK SYK | Complexes with Syk, SHP1, and Grb2, with β2 integrin | Ganju et al. (2000); Miura et al. (2000) |
| PTP non-receptor type 11 (SHPTP2 / SHP2) | Pyk2 substrate of SHPTP2; interaction involves pY402 but not SHP2 SH2 | Chauhan et al. (2000) |
| PTP non-receptor type 12 (PTP-PEST / PTPG1) | PTP-PEST dephosphorylates pY402, pY579 and pY580 | Lyons et al. (2001) |
| PTP non-receptor type 6 (SHPTP1 / SHP1) | SHPTP1 prevents Pyk2 phosphorylation; co-IP | Kumar et al. (1999); Ganju et al. (2000) |
| Ras GTPase-activating protein 1 (RasGAP / p120GAP) | Complex with pl90 RhoGAP (pi90), RasGAP, c-Abl, pl30cas, paxillin; C2 domain of RasGAP | Chow et al. (2000); Zrihan-Licht et al. (2000) |
| Rho GTPase-activating protein 5 (p190RhoGAP) | Complex with pl90 RhoGAP (pi90), RasGAP, c-Abl, pl30cas, paxillin | Zrihan-Licht et al. (2000) |
| Rhophilin-2 | pUS28-expressing RSMC; IP, tandem MS; low levels | Vomaske et al. (2010) |
| RTEL-1 | pUS28-expressing RSMC; IP, tandem MS | Vomaske et al. (2010) |
| SH3 domain-containing kinase-binding protein 1 (CD2BP3 / SETA / RUK / CIN85) | Complex with SETA/CIN85/Ruk and AIP1; HEK293 cells; co-IP | Schmidt et al. (2003) |
| TCF-4 | pUS28-expressing U373; IP, tandem MS | Vomaske et al. (2010) |
| PTP (TFG) Trk-fused gene | pUS28-expressing RSMC; IP, tandem MS; low levels | Vomaske et al. (2010) |
| TNF receptor-associated factor 4 (Traf4) | Complex with Hic-5 | Wu et al. (2005); Arthur et al. (2011) |
| Trio | pUS28-expressing RSMC; IP, tandem MS; low levels | Vomaske et al. (2010) |
| Tropomodulin-3 | pUS28-expressing RSMC; IP, tandem MS; low levels | Vomaske et al. (2010) |
| Tropomyosin-a1, a3, a4, -b | pUS28-expressing RSMC; IP, tandem MS; low levels | Vomaske et al. (2010) |
| Tubulin-b-2C | pUS28-expressing RSMC; IP, tandem MS; low levels | Vomaske et al. (2010) |
| USP6 oncogene | pUS28-expressing U373; IP, tandem MS | Vomaske et al. (2010) |
| VEGFR-1 / FLT-1 | Podar et al. (2002) | |
| Vimentin | pUS28-expressing RSMC; IP, tandem MS; low levels | Vomaske et al. (2010) |
IP, immunoprecipitation; MS, mass spectrometry; PTK, protein tyrosine kinase; PTP, protein tyrosine phosphatase; RSMC, rectal smooth muscle cells.