TABLE 2.

Antibiotic treatment and drug concentrations in a neurosurgery patient with augmented renal clearance and multiple abscesses in the brain due to S. intermedius infection.

Day (day 1 is first day with symptoms)	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21
Meropenem dosage	2 g × 3	→	→	→		2 g × 4	→	→	→	→	→	3 g bolus +12 g/day b	12 g/day b	16 g/day b	→	→	12 g/day b	→	→
Meropenem trough concentration (mg/L) (> 8 mg/L) a										1.3			11		23		31	17
Acyclovir	800 mg × 3	→	→	→
Betamethasone	8 mg × 4	→	→	→
Cefotaxime					3 g × 4
Metronidazole					1.5 g	0.5 g × 3	→	→	→	→	→	→	→	→	→	→	→	→	→
Vancomycin dosage						2 g bolus + 1.5 g ×3	1.5 g × 3	2 g × 3	→	2 g × 4	2 g × 3	1.5 g × 4	→	→	→	→	→	→	→
Vancomycin trough concentration (mg/L) (15–20 mg) a							6.5	9.8	9.0	22.3	11.7		14.6/12.6	12.0		15.1	19.6	18.7	19.3
Trimethoprim–sulfamethoxazole (TMP-SMX) (16 mg/ml, 80 mg/ml)									40 ml × 2
Trimethoprim trough concentration (mg/L)										2.8
Sulfamethoxazole trough concentration (mg/L)										75.8
Rifampicin										450 mg × 2	→	600 mg × 2	→
Vancomycin intrathecal dosage (mg single dosage)							10		10	10		10		20	20		20		20
Vancomycin intrathecal (CSF) trough concentration (mg/L)								<4		<4		<4		<4	<4	11.9	<4	12.4	<4

^aReference values.

^bContinuous infusion.