TABLE 1.

Quantitation of HCV RNA in plasma samples by four assays

Genotype (no. of samples)	bDNA-2		Limiting dilution		Roche Monitor version 1.0		Roche Monitor version 2.0
	Median virus load (range)	Ratioa(P value)b	Median virus load (range)	Ratio (P value)	Median virus load (range)	Ratio (P value)	Median virus load (range)	Ratio (P value)
1 (20)	3.145 (<0.2–23.51)		2.065 (0.074–49.00)		1.041 (0.100–6.800)		0.273 (0.089–1.020)
2 (20)	4.245 (<0.2–32.05)	1.24 (0.914)c	2.850 (<0.001–24.00)	1.38 (0.755)c	0.555 (<0.001–19.00)	0.53 (0.208)c	0.254 (0.015–0.428)	0.93 (0.387)c
3 (20)	1.381 (<0.2–71.04)	0.40 (0.569)c	2.400 (<0.001–33.00)	1.16 (0.968)c	0.076 (<0.001–1.500)	0.07 (<0.001)d	0.246 (0.094–1.090)	0.900 (0.409)c
4 (19)	2.239 (<0.2–39.11)	0.66 (0.955)c	1.840 (0.111–36.80)	0.89 (0.399)c	0.038 (<0.001–0.523)	0.04 (<0.001)d	0.147 (0.004–2.300)	0.54 (0.013)d
6 (16)	0.439 (<0.2–9.622)	0.131 (0.080)d	2.320 (0.184–23.20)	1.12 (0.787)c	0.184 (0.026–0.382)	0.18 (<0.001)d	0.568 (0.134–1.320)	2.08 (0.005)d

^aRatio of median virus load to that of genotype 1 samples. 

^bProbability of difference in virus load occurring by chance (Mann-Whitney U test). 

^cNot significantly different from genotype 1 samples. 

^dSignificantly different (P < 0.05) from genotype 1 samples.