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Sorafenib decreases the mRNA expression of MMPs in vivo. B16BL6 cells were inoculated into the right hind footpad of mice, and treated with sorafenib (10, 30 and 50 mg/kg). After 21 days, the mice were sacrificed, and the right footpads were harvested. The mRNA expression levels of (A) MMP-1, (B) MMP-2, (C) MMP-9 and (D) MMP-14 were measured using reverse transcription-quantitative PCR. Data are presented as the mean ± SD of three independent experiments. *P<0.05 vs. control.
