Figure 8.

Sorafenib decreases the mRNA expression of VLAs in vivo. B16BL6 cells were inoculated into the right hind footpad of mice, and treated with sorafenib (10, 30 and 50 mg/kg). After 21 days, the mice were sacrificed, and the right footpads were harvested. The mRNA expression levels of (A) VLA-1, (B) VLA-2, (C) VLA-3, (D) VLA-4, (E) VLA-5 and (F) VLA-6 were measured using reverse transcription-quantitative PCR. Data are presented as the mean ± SD of three independent experiments. *P<0.05 vs. control. VLA, very late antigen.