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Schematic diagram of the effects of sorafenib on melanoma cells. Sorafenib inhibited c-Kit, PDGFR, VEGFR, B-Raf and c-Raf activation melanoma cells with c-Kit aberration. This subsequently suppresses tumor growth and metastasis. Therefore, sorafenib may have potential clinical applications for the treatment of metastatic melanoma with c-Kit aberration. VLA, very late antigen; PDGFR, platelet derived growth factor receptor.
