Figure 3.
Dynamics of induced reentrant spiral waves in 21-mm-diameter monolayers with a central island of Kir2.1 suppression. The mapping region is 17 mm in diameter. A, Island of Kir2.1-suppressed NRVMs (indicated by white circles) acting as a source of spontaneous activity, as seen by the spread of spontaneous cardiac impulses (shown by black arrows) from an interior region of the island. B, An induced spiral wave anchored momentarily to the region of IK1 suppression (shown by white circle). C, Transition of initial spiral wave into a multi-armed spiral wave. D, Transition of initial spiral wave into a 2-armed spiral wave. E, Transition of the 2-armed spiral wave of D into a figure-of-eight reentry that later drifted to the edge of the monolayer and terminated. Reproduced from Sekar et al with permission.45