Table 1:

Major carbapenemase enzymes

Ambler class	Major enzymes	Active site	Primary geographic distribution	Treatment notes
A	KPC	Serine	United States, Colombia, Greece	Inhibited by clavulanate, tazobactam
	NMC, SME		Rare
B	VIM	Zinc	Spain, Italy, Greece	Do not hydrolyze monobactams*
	IMP		Japan, Taiwan
	NDM		India, Pakistan, Romania, Poland
D	OXA-48	Serine	Turkey, Mediterranean, Morocco	Low-level resistance against cephalosporins*

^*Are often co-occurring with ESBL enzymes that confer resistance to these classes