Table 5.

Phytosomes Related Patents on the Developed Technologies

Sr. No	Title	Novelty/Innovation	Patent No. (Year of Grant)	References
1	Phospholipid complex of curcumin having improved bioavailability	Phospholipid complexes of curcumin provide a higher systemic level of parent agent than uncomplexed curcumin.	WO2009/101551 (2009)	[295]
2	Phospholipid complexes of olive fruits or leaves extract having improved bioavailability	Olive fruits/leaves extracts bioavailability enhanced using phospholipids complexes	EP1844785 (2007)	[296]
3	Compositions comprising Ginkgo biloba derivatives for the treatment of asthmatic and allergic conditions	Compositions of the fraction gained from Ginkgo biloba for the treatment of asthma and allergic conditions	EP1813280 (2007)	[297]
4	Treatment of skin, and wound repair, with thymosin β-4	The formulation developed containing Thymosin β4 for wound healing	US/2007/ 0015698 (2007)	[298]
5	Oral compositions for the treatment of cellulite	Oral and cosmetic pharmaceutical Formulation containing Centella asiatica triterpenes, extracts of Vitis vinifera, and Ginkgo biloba flavonoids in the free or complexed form with phospholipids	US7691422 (2007)	[299]
6	Fatty acid monoesters of sorbityl furfural and compositions for cosmetic and dermatological use	The selected fatty acid monoesters of sorbityl furfural are lipophilic agents for specific anti hydroxyl radical activity	EP1690862 (2006)	[300]
7	Cosmetic and dermatological composition for the treatment of aging or photodamaged skin	The topical cosmetic or dermatological preparation containing at least one collagen synthesis-stimulating agent for anti-wrinkle treatment	EP1640041 (2006)	[301]
8	Soluble isoflavone composition	Isoflavone compositions enhanced the solubility, texture characteristics, taste, and color of the formulation	WO/2004/ 045541 (2005)	[302]
9	An anti-oxidant preparation based on plant extracts for the treatment of circulation and adiposity problems	The formulation developed having the plant extracts possessing the anti-oxidant activity for the treatment of phlebitis, hemorrhoid, arteriosclerosis, varicose vein, and elevated blood pressure	EP1214084 (2004)	[303]
10	Phospholipid complexes prepared from extracts of Vitis vinifera as anti-atherosclerotic agents	Vitis vinifera extract phospholipid complexes for the prevention and treatment of atherosclerosis.	US6297218 (2001)	[304]
11	Bilobalide phospholipid complexes, their applications, and formulations containing them	Complexes with synthetic or natural phospholipids and bilobalide (a sesquiterpene found in the Ginkgo biloba leaves) are revealed, as well as their formulation and application in inflammatory conditions and for the treatment of neuritic processes. This compound exhibited higher bioavailability than free bilobalide, hence it is applicable for parenteral and topical administration.	EP 0441279 (1991)	[305]
12	Complexes of neolignane derivatives with phospholipids, the use thereof, and pharmaceutical and cosmetic formulations containing them	Complexes of lipophilic extracts of Krameria or Eupomatia plant genus and some neolignanes isolated from the same extracts showed antibacterial, antimycotic, and antiradical activities. So it is a new active principle for the preparation of cosmetics and medicaments, as well as a good preservative in cosmetic preparations.	EP 0464297 (1990)	[306]
13	Complexes of saponins with phospholipids and pharmaceutical and cosmetic compositions containing them	The better bioavailability of saponins complexes with natural phospholipids suitable for cosmetic, pharmaceutical, and dermatological utilities	EP 0283713 (1988)	[307]
14	Complexes of flavanolignans with phospholipids, preparation thereof, and associated pharmaceutical compositions	This innovation consists of preparation lipophilic complexes of silidianin, silybin, and silicrist by non-conventional methods. Compared to individual flavanolignans, the resulted complex showed high gastrointestinal uptake followed by higher plasma levels. Because of this improved pharmacokinetic activity, the compound is applicable in the management of acute and chronic liver diseases.	EP 0209038 (1988)	[308]
15	Complex compounds of bioflavonoids with phospholipids, their preparation and use, and pharmaceutical and cosmetic compositions containing them	High lipophilia, improved bioavailability, and therapeutic properties obtained with complex compounds of flavonoids with phospholipids in comparison to free flavonoids.	EP 0275005 (1983)	[309]