Fig. 5.

Early vs. late symptomatic SMA. A PCA/CA classification and MCCV of early symptomatic (SMA 1/2) vs. late symptomatic (SMA 3) group in relation to an age-matched control group of healthy individuals between 2 months and 19 years showed clear discrimination between early and late symptomatic SMA. B Similar results were returned after excluding children under 2 years rendering age bias as confounder unlikely. PCA/CA was performed on 1,000 variables from 0.5 to 10 ppm (exclusion: see Materials and Methods) with Expl. Variance of 99.5%. The Confusion Matrix is the result of 100 Monte-Carlo-Runs (MC) with sixfold CrossValidation (CV). Space of discrimination is one representation of the modelling samples in 2-dimensions. □ represent the model-set and ○ represent the test-set. SMA: spinal muscular atrophy. CTRL: control