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. 2021 Oct 12;22(6):826. doi: 10.3892/ol.2021.13087

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Copyright: © Shen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Exosomal circRNAs affect tumor metastasis. Exosomal circPDE8A plays the role of a competing endogenous RNA, sponging miR-338 and inducing the invasive growth of tumors via the AKT, ERK, MET and MACC1 pathways. Finally, such processes result in EMT, increase the permeability of vascular endothelial cells and promote liver metastasis of pancreatic cancer. circ/circRNA, circular RNA; miR, microRNA; EMT, epithelial-mesenchymal transition; MACC1, MET transcriptional regulator MACC1; PDE8A, phosphodiesterase 8A.