Supplementary Figure 9.

Biofilms show disease-specific changes on ASV level. ASV-based differences (as determined with DESeq2) between BF^– and BF⁺ biopsies, between BF^– and areas without biofilm from BF⁺ patients (Distal-Bx), stool from BF⁺ and BF^– patients, in each disease cohort. Additional comparison between UC inflamed areas of BF⁺ (inflamed BF⁺) and BF^– patients. Size of dots represent fold-change, full dots represent up-regulation in biofilm setting, empty dots represent down-regulation. Dots are colored based on bacterial phylum, bacterial taxonomies (genera and species) have been assigned to each ASV based on the SILVA reference database. Only significant findings (P < .05 after correction for multiple comparisons) are shown. n = 35 BF⁺, n = 38 BF^–, n = 30 Distal-Bx, n = 5 inflamed BF⁺, n = 6 inflamed BF^–, n = 51 BF⁺ stool samples, n = 54 BF^– stool samples.