Figure 2.

Protein interaction network for SARS-CoV-2 infection- The protein-protein interaction network extracted for genes differentially regulated (DEGs) in CoV-2 dataset (see Methods) is shown here. Clustering identified nine functional modules for further analysis. The modules functionally corresponded with i. Response to interferon, ii. Cytokine-mediated & NFkB signaling iii. Complement & coagulation iv. JAK-STAT signaling v. Cell proliferation vi. Gap junction pathway vii. Cytokeratins viii. Keratinocyte differentiation and ix. Angiogenesis. Red node labels indicate upregulated genes and blue node labels indicates downregulated genes. Diamond node shapes indicate DEGs identified only within CoV-2 while circle indicate DEGs identified in more than one upper respiratory tract infection.