Fig. 1.

Kaplan-Meier survival curves of patients with Por differentiated and W-M differentiated HCC. a OS. b RFS. c Early RFS. d Early extrahepatic RFS. The unadjusted and adjusted HRs of reduced OS, RFS, early RFS, and early extrahepatic RFS in patients with Por HCCs were calculated using the unadjusted and adjusted Cox proportional hazard regression model. The HRs of tumor differentiation before and after the second-year follow-up were 2.24 and 1.04 (p value for effect change over time = 0.19) for OS and 1.38 and 0.61 (p value for effect change over time = 0.1) for RFS, respectively. Por, poorly differentiated; W-M, well- or moderately; HCC, hepatocellular carcinoma; OS, overall survival; RFS, recurrence-free survival; HRs, hazard ratios; CI, confidence interval.