Fig. 1.

RBD-specific IgM and Spike-specific IgG and IgA antibodies in HD (blue circles), CVID patients (green circles), CVID previously infected patients (pink circles) and XLA (red circles), before (T0, dark color circles) and one week after the second dose (T1, lighter color circles) of BNT162b2 vaccine. For each group the median is shown as a bar. * P ≤ 0.05, ** P ≤  0.01, *** P ≤  0.001, **** P < 0.0001. Positive cut-off value is represented by a dashed line. N = 28 HD, N = 34 CVID, N = 6 XLA patients, and N = 7 CVID previously SARS-CoV-2 infected