TABLE 1.
Baseline Characteristics of the Cohort
| Recurrent hemispheric syndrome at baseline | No recurrent hemispheric symptom at baseline | ||||
|---|---|---|---|---|---|
| Surgical | Nonsurgical | Surgical | Nonsurgical | P value | |
| Participants, No. | 50 | 50 | 47 | 48 | |
| Age, mean (SD), years | 58.9 (7.6) | 57.1 (9.6) | 57.8 (10.4) | 59.0 (8.4) | .68 |
| Male, No. (%) | 31 (62) | 35 (70) | 38 (81) | 26 (54) | .04 |
| Race White, No. (%) | 47 (94) | 47 (94) | 41 (87) | 45 (94) | .64 |
| Hypertension, No. (%) | 40/49 (82) | 43 (86) | 36 (77) | 34/47 (72) | .37 |
| Hyperlipidemia, No. (%) | 42/49 (86) | 46 (92) | 37 (79) | 40/47 (85) | .33 |
| Diabetes mellitus, No. (%) | 10/49 (20) | 14 (28) | 11 (23) | 9/47 (19) | .73 |
| Cigarette smoking, No. (%) | (n = 49, 1 missing) | .38 | |||
| Current | 17 (35) | 24 (48) | 16 (34) | 13 (28) | |
| Former | 30 (61) | 22 (44) | 26 (55) | 29 (62) | |
| Previous myocardial infarction, No. (%) | 5 (10) | 11 (22) | 6 (13) | 3 (6) | .11 |
| Previous stroke, No. (%) | 33/48 (69) | 27 (54) | 11 (23) | 8/46 (17) | <.01 |
| Entry event type, No. (%) | <.01 | ||||
| Stroke | 17 (35) | 23 (46) | 35 (74) | 39 (81) | |
| Transient ischemic attack | 32(64) | 27(54) | 12(26) | 8(17) | |
| Unknown | 1(2) | 1(2) | |||
| Entry event side, No. (%) | .55 | ||||
| Left | 23 (46) | 28 (56) | 20 (43) | 25 (52) | |
| Right | 27(54) | 22(44) | 27(57) | 23(48) | |
| Entry event to randomization, median (IQR), days | 62 (59) | 60 (60) | 79 (84) | 86 (50) | .04 |
| PET ratio, median (IQR) | 1.21 (0.12) | 1.22 (0.14) | 1.21 (0.15) | 1.21 (0.13) | .66 |
| Modified Rankin score, median (IQR) | 1.0 (1.0) | 1.0 (1.0) | 1.0 (2.0) | 1.0 (1.0) | .87 |
| NIHSS, median (IQR) | 1.0 (3.0) | 1.5 (3.0) | 1.0 (3.0) | 1.0 (3.0) | .73 |
| SSQoL (Summary), mean (SD) | 3.55 (0.89) | 3.60 (0.84) | 3.92 (0.83) | 3.82 (0.78) | .10 |
| Systolic blood pressure, mean (SD), mm Hg | 133 (16) | 138 (19) | 134 (15) | 140 (21) | .13 |
| Diastolic blood pressure, mean (SD), mm Hg | 77 (10) | 77 (11) | 76 (11) | 78 (9) | .71 |
| LDL-cholesterol, median (IQR), (mg/dL) | 100 (58) (n = 35) | 98 (41) (n = 36) | 94 (55) (n = 41) | 100 (34) (n = 33) | .96 |
| Hemoglobin A1C, mean (SD), (%) | 5.8 (0.6) (n = 38) | 5.9 (0.6) (n = 41) | 5.6 (0.9) (n = 45) | 5.7 (0.6) (n = 33) | .46 |