FIG. 3.
BL41 cells treated with cisplatin fail to complete mitosis and instead undergo apoptosis. Cells were electronically gated as described for Fig. 2C. A significant proportion of untreated BrdU-labeled BL41 cells (A) have returned to G1 phase by 12 h, while BL41 cells treated with cisplatin (B) are unable to complete mitosis (compare graphs 5 in panels A and B). The apparent increase in cells in S phase (indicated with an arrow) in graph 6 is derived from cells which have undergone apoptosis from G2/M.