Flow screen in toluene/TMEDA.
| ||||||
|---|---|---|---|---|---|---|
| Entry | X (M) | Toluene : TMEDA | Flow ratea (mL min−1) | Residence time (min) | Yieldb | SMb,c |
| 1d | 1.1 | N/Ae | 5 | 2.6 s | 0% | 65% |
| 2 | 1.1 | 4 : 1 | 1 | 5 | 62% | 8% |
| 3 | 1.1 | 4 : 1 | 3 | 1.67 | 60% | 29% |
| 4 | 1.1 | 4 : 1 | 5 | 1 | 59% | 29% |
| 5 | 1.1 | 4 : 1 | 10 | 0.5 | 49% | 40% |
| 6 | 0.8 | 4 : 1 | 5 | 1 | 46% | 55% |
| 7 | 1.1 | 1 : 1 | 5 | 1 | 73% | 14% |
| 8 | 1.1 | 1 : 1 | 3 | 1.67 | 70% | 10% |
| 9 | 1.1 | 1 : 1 | 10 | 0.5 | 70% | 8% |
a
Flow rate from each pump; after junction, flow rate is doubled.
b
As determined by 1H NMR spectroscopy in the presence of 1,3,5-trimethoxybenzene.
c
Remaining starting material.
d
Using a 28 cm length of tubing as a reactor.
e
No TMEDA used.