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. 2021 Sep 15;12(40):13413–13424. doi: 10.1039/d1sc04176b

Optimisation of cumyl deprotection.

graphic file with name d1sc04176b-u4.jpg
Entry Loading of 10% Pd/C (mol%) Reaction time (h) Conversiona Yieldb
1 20 1 100% 80%
2 10 1 100% 78%
3 5 4 100% 75%
a

As determined by 1H NMR spectroscopy in the presence of 1,3,5-trimethoxybenzene.

b

Isolated yield.