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Residues involved in the disruption of the ionic lock are shown at t = 0.5 nsec (left panel) and 7.5 nsec (right panel) during MD simulation with the inactive D2-I212F model. Ballesteros-Weinstein numbering for the colored residues is Asp1313.49 (green), Arg1323.50 (light blue), Phe2125.61 (yellow), Leu2165.65 (red), and Glu3686.30 (magenta).
