Fig. 3. (a) Reaction scheme of compound 3 reacting with Boc-Cys-OMe to form compound 14. (b) Percentage of compound 3 and 14 as determined by the integration of the HPLC peak in comparison to the internal standard at different time points. (c) Experimental determination of the second-order rate constant of the model reaction between compound 3 (1 mM) and Boc-Cys-OMe (1 mM). Details about the calculation and kinetics data were demonstrated in Section 4 in ESI.†.
