Fig. 2. Structural comparison of the deposited PDB structures of the helicase dimer in SARS-CoV-1 (PDBID: 6jyt, a), SARS-CoV-2 (PDBID: 6zsl, b), SARS-CoV-2 in complex with NSP7 NSP8 and NSP12 (PDBID: 6xez, c) and SARS-CoV-2 with a small fragment of ssRNA bound in complex with NSP7 NSP8 and NSP12 (PDBID: 7cxm, d). The interaction between the two helicase monomers differs depending on the experimental method used to resolve the structures.
