Figure 4. In vitro selection of 2–36 escape viruses.
(A) Neutralizing activity of 2–36 against viruses at different passages.
(B) Spike mutations found in viruses at different passages
(C) Model of 2–36 in complex with the SARS-CoV-2 S trimer highlighting mutations in red. CDR H3 Tyrosine 98 makes van der Waals contacts with RBD residue 378 as shown as electron density map mesh in the subpanel.
(D) The selected mutations were introduced into pseudoviruses and then tested for neutralization sensitivity to 2–36.
(E) The frequency of the selected mutations in circulating in infected patients (data updated to Oct 13th, 2021).